BackgroundChimeric antigen receptor (CAR) T-cell therapy represents the most advanced immunotherapy against relapsed/refractory B cell malignancies.While cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome are distinctive, known CAR T-cell acute adverse events, hematological toxicity has been increasingly reported.C
High-resolution genotyping of Lymphogranuloma Venereum (LGV) strains of Chlamydia trachomatis in London using multi-locus VNTR analysis-ompA genotyping (MLVA-ompA).
BackgroundLymphogranuloma venereum (LGV) is caused by Chlamydia trachomatis strains with ompA genotypes L1 to L3.An LGV epidemic associated with the L2b genotype has emerged in the past few decades amongst men who have sex with men (MSM).C.trachomatis genotypes can be discriminated by outer membrane protein A gene (ompA) sequencing, however this me
Comparison of Search-Based Software Engineering Algorithms for Resource Allocation Optimization
A project manager balances the resource allocation using resource leveling algorithms after assigning resources to project activities.However, resource leveling does not ensure optimized allocation of resources.Furthermore, the duration and cost of a project may increase after leveling resources.The objectives of resource allocation optimization us
Features of intellectual property reflection in accounting and in financial statements
Intellectual property is a powerful tool that helps the company feel confident LIGHTENING CREAM in a competitive environment, attract investment, expand sales markets, thereby improving its financial position.The correct reflection of intellectual property in the accounting is of great importance for the correct disclosure of information in the fin
Gammaherpesviral gene expression and virion composition are broadly controlled by accelerated mRNA degradation.
Lytic gammaherpesvirus infection restricts host gene expression by promoting widespread degradation of cytoplasmic mRNA through the activity of the viral endonuclease SOX.Though generally assumed to be selective for cellular transcripts, the extent to which SOX impacts viral mRNA stability has remained unknown.We addressed this issue using the mode